The home side are also looking to exact revenge on their visitors following a 3-1 defeat in February's reverse fixture.
Perth Glory were involved in a share of the spoils for the second game running as they played out a 1-1 draw against Wellington Phoenix on Sunday.
Tomer Hemed's first-half strike was cancelled out just past the hour mark by Bruno Fornaroli, after which Callum Timmins opened his account for the campaign to give Richard Garcia's men the lead in the 74th minute.
The Glory have now gone six league games without tasting defeat, picking up 14 points from an available 18 in that span.
However, they are still four points away from the last playoff spot and need to secure maximum points from their last two matches to stand any chance of qualifying.
Brisbane Roar failed to record a third consecutive victory as they were beaten 2-0 by Western Sydney Wanderers on Sunday.
Nonetheless, The Roar currently occupy the last playoff spot, two points ahead of their nearest challengers with a game in hand.
Wednesday's visitors only need three points from their final two games to make the playoffs for the 10th time in the last 11 years.
Bruno Fornaroli is now up to 12 league goals this term following his equaliser last time out, one shy of last campaign's tally of 13.
With only a four-day recovery window from the last game, Richard Garcia could make some alterations to his starting XI for this one.
Riku Danzaki has been instrumental to the away side's push for a spot in the post-season having scored in six of their 10 A-league victories.
His eight goals in general have been worth 11 points, which is remarkable especially for a 21-year-old in his first full top-flight season.
Kai Trewin is expected to fill in for Tom Aldred after coming on as a first-half substitute for his Scottish teammate in the last match.
Brisbane Roar possible starting lineup:
Young; Brown, Gillesphey, Trewin, Neville; Champness, Akbari, O'Shea, Brindell-South; Parsons, Danzaki
Perth Glory possible starting lineup:
Reddy; Lachman, Aspropotamitis, Geria; Ota, Bodnar, Timmins, Ingham; Castro, Keogh, Chianese
We say: Brisbane Roar 2-2 Perth Glory
Both sides have it all to play for in this one as the season reaches its conclusion. We are anticipating an end-to-end and entertaining affair with the teams having to settle for a point apiece in the end.