Liverpool striker Christian Benteke suffered a thigh injury in his club side's Premier League clash against West Ham United and so drops out of the Red Devils squad, Everton forward Romelu Lukaku taking his place up front.
Jason Denayer, Nicolas Lombaerts and Dries Mertens, who started in their country's 1-0 defeat at Wales, are relegated to the subs' bench in place of Vincent Kompany, Thomas Vermaelen and Marouane Fellaini.
Bosnia, who sit second from bottom in the group but remain in contention on eight points, remain unchanged from their 3-1 victory over third-placed Israel.
Belgium: Courtois, Vertonghen, Kompany, Vermaelen, Alderweireld, Witsel, Fellaini, De Bruyne, Nainggolan, Hazard, Lukaku
Bosnia-Herzegovina: Begovic, Kolasinac, Mujdza, Besic, Spahic, Pjanic, Visca, Medunjanin, Lulic, Dzeko
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