The hamstring injury that Bukayo Saka sustained against Tottenham Hotspur kept him out of the midweek defeat to Olympiacos, but he has been passed fit for this game, although Willian was also ruled out of the Europa League tie with a calf problem and remains doubtful.
With Saka not expected to be thrown back into the first XI, Nicolas Pepe looks set for another run-out on the right-hand side, but Willian was unlikely to successfully challenge Emile Smith Rowe for a spot on the left flank.
Arteta also has a big call to make up top after Pierre-Emerick Aubameyang's wasteful evening against Olympiacos, and with Alexandre Lacazette boasting four goals from his last five top-flight matches against West Ham, the Frenchman could lead the line this week.
Two expected changes in the engine room should see Martin Odegaard demote Dani Ceballos back down to the bench, while Thomas Partey will once again line up alongside Granit Xhaka in place of Mohamed Elneny.
Arteta appears to have settled on Gabriel Magalhaes and David Luiz as his first-choice centre-back pairing, although Pablo Mari impressed in the rearguard before being dropped and will hope to be given another chance again soon.
Arsenal possible starting lineup:
Leno; Cedric, Luiz, Gabriel, Tierney; Xhaka, Partey; Pepe, Odegaard, Smith Rowe; Lacazette
Watch the Sports Mole Football Shorts prediction for this game below: