Athletes who are caught intentionally using performance-enhancing drugs will now receive an automatic four-year ban.
New rules to the world anti-doping code that came into effect on January 1, have increased the suspension for cheats from the previous two years to four years.
Anyone who misses three tests within a 12-month period will be suspended for two years, but dopers who cooperate and provide crucial information after being caught could face reduced bans.
"Successful implementation will mean an innovative and robust anti-doping programme that reaches further than ever before, to more athletes, more support personnel and more sport lovers, all of who want to be part of sport free from doping," minister for sport, tourism & equalities Helen Grant said in a statement via UK Anti-Doping.
"We will see tougher sanctions - not just for athletes, but also for those who assist in the doping process."
Paula Radcliffe claimed last month that nations should be banned for frequent doping offences.