Harbaugh was questioned by reporters regarding whether he would keep second-year man Cam Johnson, who has impressed in pre-season, on his squad despite having several quality options on the outside already.
"Five total? Yeah, you could," Harbaugh told CSN Bay Area.
"After tonight and the way Cam Johnson played, can you? Heck, yeah, you can. We're the San Francisco 49ers. We can do whatever we want."
San Francisco open their regular season campaign on September 8 against the Green Bay Packers.