Brown made his first appearance of the season during last Sunday's game against the Oakland Raiders, rushing for 115 yards and a touchdown to secure the win.
Manning - who is not enjoying his best season in the passing game - said the return of Brown is excellent news for the team going forward.
He told Giants.com: "It was great getting Andre back. He rushed the ball 30 times and over 100 yards and was big in finishing out that game when we had to run it six straight times. He had two first downs and didn't give Oakland the ball back.
"He did a great job of just getting positive yardage, putting us in a lot of third and manageable situations running it down in the red zone. I think that was big and hopefully he can continue to play well. He can slow down that pass rush a little bit to get the ball down the field."
The Giants currently sit in third spot in the NFC East, and face the Green Bay Packers on Sunday night.