Payton took one of the biggest gambles in NFL history when he opted to go for an onside kick in Super Bowl 44 to take away a possession away from the Indianapolis Colts and Peyton Manning.
The play worked and was instrumental in their triumph at Sun Life Stadium but Payton believes that every game is different.
He told the club's official website: "We will look closely at situations, timing in the game. A lot of times the decision to go for it on fourth down or hypothetically a two-point play is based on whether you still have a play you like.
"Sometimes, say in short-yardage situations, you've run a play you really like, converted, maybe you would run another one. A lot of times it depends on if you have that play still that you haven't shown. That factors in more than you think.
"I think it also is based on the game in itself and how it is unfolding, what you are doing defensively and what you are doing offensively and paying attention to that and trusting your instincts when the time comes. Each game is different."
The Saints face the Carolina Panthers in a crucial NFC South showdown on Sunday.