New England's defense started on a high note as Kyle Arrington stoke the ball from CJ Spiller and presented Tom Brady with a short field. He took full advantage and found Julian Edelman for a nine-yard touchdown to give his side the lead.
The Patriots had the chance to extend their advantage but could not convert on third down as Julian Edelman was brought down by Aaron Williams. Stephen Gostkowski, however, nailed a 48-yard field goal to give Bill Belichick's side a 10-0 lead.
Brady got his offense going again as he found Edelman again for another touchdown with an eight-yard strike.
However, just before the half-time interval, Brady was intercepted by Justin Rogers and Bills quarterback EJ Manuel fired an 18-yard strike to fellow rookie Robert Woods to bring his side back into the game at 17-14.