Bush ran for 139 yards in the first meeting of the two sides in the Lions' 40-32 victory over the Bears at Ford Field.
He told the Detroit Free Press: "Well, yeah we have to be able to take advantage of obviously the holes that we see. Obviously they're going to do their part this week at trying to plug up some of those holes.
"And it's our job to try to exploit some of those. We feel like there is some room for us to take advantage of them in the run game. We just have to make sure we go in and play fundamentally sound."
The Lions are currently 5-3 in their season going into week 10.