Spikes will be in action against his former team for the first time since he left the Patriots franchise earlier this year, and he is hopeful that his new side can mark the match with a victory.
He told reporters: "They drafted me, I spent a lot of time with them, a few years. I had a lot of success. I'm anxious for this.
"I'm not going to say it's personal, but it's big for this organisation, it's big for Buffalo. We all need this. Not just the players, the entire city.
When asked if the occasion would be emotional, Spikes added: "Absolutely. It's my former team. I've got friends still over there. I'm excited. I've been waiting for this for a while now."
The Bills have a 3-2 record this season heading into their crucial AFC East clash.