Arizona Cardinals, Baltimore Ravens and Cleveland Browns will all compete in London for the first time in 2017, while regulars Jacksonville Jaguars will also return.
The NFL has announced the full set of fixtures to be played in London next year, which includes debuts in the English capital for three different franchises.
Wembley Stadium and Twickenham Stadium will host two matches apiece, with Arizona Cardinals, Baltimore Ravens and Cleveland Browns to compete in the UK for the first time.
The Ravens will face Jacksonville Jaguars at Wembley, while New Orleans Saints take on the Miami Dolphins at the same venue in the first of the scheduled fixtures.
Twickenham will then welcome Minnesota Vikings and Cleveland Browns, with the Cardinals and Los Angeles Rams meeting in week eight to round things off in the 10th-year anniversary of the NFL's association with the United Kingdom.