The West Country outfit will go into the match five points adrift of the top four, but their dreams will officially come to an end if Northampton Saints defeat Sale Sharks.
Their task is made all the more difficult with a fixture against a Saracens side who have won their last six league games in a row.
Sarries introduces six new faces as they rest a number of players ahead of the playoffs, with Owen Farrell, Richard Wigglesworth and Steve Borthwick among those selected by director of rugby Mark McCall.
Gloucester: Goode, Wyles, Tomkins, Farrell, Strettle, Hodgson, Wigglesworth, Joubert, Fraser, Wray, Hargreaves, Borthwick, Stevens, Smit, Gill
Replacements: George, Vunipola, Nieto, Kruis, Burger, Spencer, Taylor, Maddock
Saracens: Cook, Sharples, Trinder, Twelvetrees, May, Burns, Robson, Wood, Britton, Knight, Savage, Lokotui, Kalamafoni, Qera, Morgan
Replacements: D'Apice, Murphy, Thomas, Buxton, Hazell, Lewis, Mills, Thomas
Sports Mole says: Saracens to continue their winning run