Sebastian Prodl, Valon Behrami and Stefano Okaka also come back into the side, with Costel Pantilimon, Craig Cathcart, Jerome Sinclair, Brandon Mason and Odion Ighalo the men to make way from that 2-0 win here seven days ago.
Visitors Boro, with just one win in their last six top-flight outings, appear to have reverted shape by switching to a five-at-the-back system for their trip to the capital.
Out go Brad Guzan, Max Clayton, Antonio Barragan, Gaston Ramirez and Adama Traore, while new signing Rudy Gestede is among the Boro subs as they aim to capitalise on their opponents' own poor run of league form.
Watford: Gomes; Kaboul, Prodl, Britos; Kabasele, Doucoure, Behrami, Capoue, Holebas, Deeney, Okaka
Subs: Pantilimon, Kabasele, Mason, Watson, Doucoure, Sinclair, Okaka
Middlesbrough: Valdes; Chambers, Bernardo, Gibson; Fabio, De Roon, Leadbitter, Forshaw, Friend; Stuani, Negredo
Subs: Guzan, Fry, Clayton, Traore, Downing, Fischer, Gestede