The Russian side are three points behind second-placed Swansea City and will seal their progress if they win and the Welsh side suffer a surprise defeat to St Gallen with a four-goal swing.
Valencia welcome Kuban to Spain knowing that they will finish at the top of Group A thanks to four victories and one loss in their previous five games.
The hosts are still without injured goalkeeper Vicente Guaita, while the visitors have no new injury problems.
Possible starting lineups
Valencia: Alves; Barragan, Ruiz, Mathieu, Bernat; Feghouli, Romeu, Canales, Parejo, Guardado; Jonas
Kuban: Belanov; Kozlov, Xandao, Dealbert, Bugaev; Ignatyev, Tilsov, Kabore, Bucur; Popov, Balde
Sports Mole says: 2-0