If either nation are to realise their ambition of qualifying for next year's World Cup as group winners, then they must not lose this clash in Kiev.
Visiting England currently top the standings on goal difference ahead of Montenegro with 15 points, while Ukraine are third and just a point worse off. Both teams have a game in hand on the Montenegrins, so a victory at the Olympic Stadium would make them the firm favourites for qualification.
Roy Hodgson will be without Manchester United striker Danny Welbeck for the trip because of suspension, which in turn is likely to see Rickie Lambert make only his third appearance for the Three Lions. James Milner's defensive abilities may also result in him being given a wide berth.
The teams shared a 1-1 draw earlier in the qualification process at Wembley, but the last time that they met on Ukrainian soil, Wayne Rooney scored the only goal of the game at Euro 2012.
Possible starting lineups
Ukraine: Pyatov; Shevchuk, Fedetskiy, Rakitskiy, Khacheridi; Tymoshchuk, Edmar, Konoplyanka, Yarmolenko; Devic, Seleznyov
England: Hart; Walker, Cahill, Jagielka, Cole; Milner, Gerrard, Lampard, Wilshere, Walcott; Lambert
Sports Mole says: 1-1