It was Southampton that dominated the first period, but neither side could make the breakthrough as it remained goalless at the interval.
The Saints continued to enjoy most of the possession in the second period, but a thunderbolt from Gareth Bale in the latter stages secured a vital win for Spurs.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
SPURS: Lloris; Walker, Dawson, Vertonghen, Assou-Ekotto; Lennon, Dembele, Huddlestone, Dempsey; Bale, Defoe
SOUTHAMPTON: Boruc; Clyne, Fonte, Hooiveld, Shaw; Cork, S. Davis, Guly, Lallana; Rodriguez, Lambert