The hero for the North Londoners was Harry Kane, who netted four goals to take him to 26 for the season and a two-strike cushion in the race for the golden boot.
Son Heung-min also scored twice as Spurs thoroughly outclassed a Leicester side who were made to settle for what turned out to be a consolation goal from Ben Chilwell.
Read below to see how the action unfolded at the King Power Stadium.
9.43pmThat will be all from Sports Mole for this match. Thank you for joining us this evening and we hope to see you again soon. Goodbye for now.
9.42pmThe full-time whistle goes at the King Power Stadium and Leicester are delighted to experience the end of this game. Kane and Son have run riot in the East Midlands to cap a scintillating display from the visitors. Leicester weren't all that bad, it is just that Spurs were that good.
90+3 minFULL TIME: Leicester City 1-6 Tottenham Hotspur
90+2 minAside from the ball not going through the legs of a defender, Kane nets a replica of his third goal. That's all you need to know.
90+2 minGOAL! Leicester City 1-6 Tottenham Hotspur (Kane)
90 minThere will be three minutes of added-on time.
89 minKane has been borderline greedy in this second half but he gets his rewards. He should probably pass to Janssen but instead, he shoots through the defender's legs and finds the back of the net from 20 yards.
89 minGOAL! Leicester City 1-5 Tottenham Hotspur (Kane)
85 minSUBSTITUTION! It is time to see Filip Lesniak for his Premier League debut. He replaces Dembele. Just before his introduction, Janssen sent a powerful effort just over the bar.
84 minCHANCE! Kane is desperate for his hat-trick, and the goal which would take him to the top of the Premier League scoring charts. Janssen backheels the ball into his path but he can't find the bottom corner from 20 yards.
83 minThis match is starting to peter out just a touch, but that's no surprise because it has been played at a relentless pace.
80 minBOOKING! Alli draws a foul out of Simpson on the edge of the penalty area and he, too, goes into the book.
78 minSUBSTITUTIONS! Spurs' first change sees Vincent Janssen handed some minutes in place of Son, who is reacting well to being brought off when on his hat-trick.
For Leicester, Ahmed Musa is introduced for Vardy.
75 minBOOKING! Moments later, Gray goes into the book for a late challenge on Davies.
74 minSHOT! To Leicester's credit, they are still pushing for goals. Substitutes Gray and Slimani link up with the former passing the ball through to his teammate but his low shot is easily saved by Lloris.
71 minThis is a sensational performance from Spurs. Sissoko starts a break-away involving Kane and Son and after Kane passes to his teammate, he expects the ball back. However, Son holds onto the ball before checking inside and curling into the bottom corner from 20 yards.
71 minGOAL! Leicester City 1-4 Tottenham Hotspur (Son)
66 minSUBSTITUTION! Shakespeare decides that he needs to throw on another offensive-minded player and that leads to Demarai Gray replacing Benalouane.
65 minBOOKINGS! Both Sissoko of Spurs and Albrighton of Leicester are cautioned for separate fouls on either flank in the space of 60 seconds.
63 minMaybe it isn't game on after all. Alderweireld's cross to the back post finds Wanyama and after his header across goal takes a nick off a defender, Kane has the simple task of heading into the net from two yards out.
63 minGOAL! Leicester City 1-3 Tottenham Hotspur (Kane)
60 minGame on at the King Power! Vardy should have been flagged offside but he is adjudged to have beaten the offside trap and he gets past Lloris around 35 yards from goal. Leicester eventually work the ball to Chilwell and he shows remarkable composure to take on a defender before slotting the ball into the net with Dier on the line.
60 minGOAL! Leicester City 1-2 Tottenham Hotspur (Chilwell)
57 minSHOT! Back come Spurs through Kane and Son, but after the first scorer sets up the second, the South Korean sends an acrobatic effort off target.
53 minSHOT! Leicester are pressing and Spurs are making mistakes. Albrighton sees a shot blocked but the ball ends up with Mahrez, who drills a low effort into the hands of Lloris.
52 minSHOT! Shakespeare's side are the better team at the start of this half but they are yet to trouble Lloris. Amartey tried his best to force the goalkeeper into action but his strike went well over the crossbar.
47 minCHANCE! Leicester are straight onto the front foot and Benalouane is the first to get an effort on goal after meeting a free kick, but his header goes over the bar.
46 minWe are back underway in the East Midlands. As predicted, Islam Slimani has replaced Okazaki.
8.33pmThe half-time whistle goes at the King Power Stadium and Spurs fully deserve to hold a 2-0 lead at this stage of the match. In all fairness, they should probably be further in front but regardless of the scoreline, they have outclassed Leicester thus far.
45+1 minHALF TIME: Leicester City 0-2 Tottenham Hotspur
42 minNot long to go until half time and I think Leicester will appreciate the sit down. They are chasing shadows at the minute.
39 minCHANCE! This is as one-sided as I can remember a game being all season. A cross into the box finds the head of Dier, but his glancing effort is kept out by Schmeichel. Leicester haven't been all that bad, but Spurs have been mesmeric.
36 minMy word. What a goal. Spurs are toying with Leicester and a patient build-up ends with a brilliant finish from Son, who hooks the ball in on the volley after Alli's dinked pass through the defence.
36 minGOAL! Leicester City 0-2 Tottenham Hotspur (Son)
32 minVardy is causing the Spurs defence numerous problems with runs in behind but aside from that one save made by Lloris, he hasn't had much joy in getting shots on goal. It wouldn't surprise me to see Slimani introduced - for Okazaki - early in the second half to give the visitors a different issue to deal with.
28 minCHANCES! Spurs look superb tonight. All credit to Pochettino for how he has motivated his team. After Alli sees a header saved by Schmeichel, the Spurs midfielder is denied from distance by the Danish stopper.
25 minThis is an excellent goal. Alderweireld's long ball sees Son beat the offside trap by inches and after biding his time to get Kane involved, he picks out his teammate who does well to finish into the bottom corner from six yards. He now sits one behind Lukaku.
25 minGOAL! Leicester City 0-1 Tottenham Hotspur (Kane)
21 minCHANCE! This is equally impressive and ambitious from Kane. He pressurises Benalouane into a mistake to create a chance for himself, but after deciding to shoot from 25 yards out, he did not come close to finding the target.
17 minSHOT! It's Sissoko's turn now. Kane's free kick is poor but it ricochets off the wall and into the path of Sissoko, who fires just over from 30 yards.
15 minCHANCE! It has been a lively old start at the King Power. Alli charges down the ball and Son ends up with a chance in front of goal, but he blazes over from inside the penalty area. Pochettino is none too pleased.
13 minSHOT! Amarety isn't known for his goals but he tries to get in on the act with a long-range half-volley but although a deflection helps the ball onto goal, Lloris makes a comfortable save.
9 minCHANCE! Vardy should be doing better from here. He find himself in time and space just inside the area but he fires the ball straight at a grateful Lloris.
8 minSHOT! Son has been superb since the turn of the year and he looks a real threat at the start of this game. A sharp turn on the edge of the area gives him the chance to get a shot on goal but he curls his effort just over the bar.
5 minCHANCE! Excellent from Kane who slides the ball through to Son but just at the point where the South Korean was about to shoot, Chilwell got back to poke the ball out for a corner.
4 minThe King Power is absolutely rocking but so far, the atmosphere hasn't helped either side create a chance on goal. Spurs are playing three at the back with Sissoko at right wing-back. Maybe that's a ploy from Pochettino to force the Frenchman to work...
7.42pmIt's time for the two teams to make their way out in front of a capacity crowd at the King Power Stadium. It appears that Shakespeare is all set to get the managerial job at the club on a permanent basis, but a result this evening would certainly help his cause.
7.37pmPREDICTION! Unlike last night's match between Southampton and Manchester United, I expect plenty of goals in this contest. Leicester have an excellent home record but even those the pressure is off Spurs, we think that they will have enough to run out convincing winners. Kane also needs goals and we think he will net a couple in a 3-1 success.
7.33pmInjuries to both Wes Morgan and Robert Huth means that Chilwell gets the chance to make his sixth Premier League start of the season at left-back. I haven't watched the young Englishman on too many occasions this season but against Atletico Madrid and Manchester City, he hasn't looked out of place and Leicester could have the position sorted out for a number of years if they can help the 20-year-old along the right path.
7.30pmSpurs spent big money on Sissoko during the summer but tonight, he is making just his eighth start in the Premier League. The North London outfit certainly haven't got value for money from the £30m signing, but he has been provided with the opportunity to impress his manager - or is that potential buyers ahead of an exit?
7.26pmWhile the title race may be done and dusted, the pursuit of the Premier League's golden boot certainly isn't. Three players still have realistic hopes of gaining their hands of the prize, and Harry Kane will move level with Romelu Lukaku if he can net a double this evening. Alexis Sanchez is currently one adrift of the Everton forward. To take a look at the full list, click here.
7.22pmThere's a greater gap in the form standings than you may have expected. Over the last half-a-dozen matches, Spurs have recorded eight more points than the Foxes but it is worth noting that Leicester have travelled to both Arsenal, Manchester City and Everton during that time.
7.19pmThe reverse fixture took place all the way back in October and it represented the last time in which a visiting team prevented Spurs from winning at White Hart Lane. Vincent Janssen had put Spurs into the lead just before the break but shortly after half time, Ahmed Musa found an equaliser. Neither player has done much since then! Click here to read back on that match.
7.12pmHEAD TO HEAD! Tonight's fixture represents the 108th time in which the two clubs have met in a competitive match, with Spurs claiming 52 victories in comparison to 34 wins for Leicester. Due to their matches in the FA Cup, there have been as many as eight matches played since the start of 2014, with Spurs claiming three triumphs and three draws during that period.
7.07pmAs for Spurs, Pochettino has taken the opportunity to tinker with his squad. Mousa Dembele and Moussa Sissoko both start, with Eric Dier moving back to right-back. Kieran Trippier is absent with concussion while Christian Eriksen only features among the substitutes. Filip Lesniak and Samuel Shashoua are both included on the bench for the first time.
7.03pmShakespeare has made just the one alteration to the team which started the match away at Manchester City last weekend, with Daniel Amartey coming in for the injured Andy King. It means Christian Fuchs stays in the centre of defence alongside Yohan Benalouane, with Ben Chilwell remaining at left-back. Islam Slimani is on the bench, with Shinji Okazaki getting the nod after his brilliant volley at the Etihad Stadium.
6.59pmTOTTENHAM HOTSPUR SUBSTITUTES: Vorm, Wimmer, Lesniak, Shashoua, Eriksen, Nkoudou, Janssen
6.54pmWhile Spurs will remain in the runners-up spot regardless of how they fare over the coming days, Leicester could finish as high as eighth and as low as 15th. It means that we should expect a motivated team to take to the pitch this evening but the problem for Shakespeare is that he is without five first-teamers for the match in the East Midlands. Let's see who he, and Mauricio Pochettino, have selected in their respective starting lineups.
6.50pmDuring the closing stages of last season, Leicester and Spurs were battling it out for the league title but although there is little at stake this evening, we should still see two quality teams on show at the King Power Stadium. Leicester have impressed since Craig Shakespeare replaced Claudio Ranieri, while Spurs have guaranteed second place in the standings after putting together the strongest run of form since the turn of the year.