Spurs will travel to Craven Cottage looking to end a two-match losing streak having followed up last weekend's loss to Liverpool with a 1-0 defeat at the hands of Gent in the Europa League this evening.
Despite their alarming dip in form, Pochettino will take the opportunity to use some of his fringe players and hinted that Harry Kane will be one of those rested after he picked up a knock to his knee during the defeat in Belgium.
"I think we need to assess some players. Harry Kane got a knock on his knee, different players too," he told reporters.
"We need to refresh the team and we'll do that. Tottenham will play in Fulham on Sunday. It's not the name of the players, it's the club. We'll see, but we'll put out a team with aims to win and be ready again to compete."
Spurs have not lost three matches in a row since March 2013, when Tim Sherwood was in charge.