The England international, who usually plays as a defensive midfielder, has dropped into the role as a result of Toby Alderweireld's injury.
Heung-min Son comes into the fold to provide support to striker Vincent Janssen, while Victor Wanyama, Dele Alli, Erik Lamela and Christian Eriksen keep their places following last weekend's 1-1 draw with West Bromwich Albion.
Bayer Leverkusen: Leno; Bender, Tah, Toprak, Henrichs; Kampl, Aranguiz, Mehmedi, Calhanoglu; Hernandez, Kiessling
Tottenham Hotspur: Lloris; Trippier, Dier, Vertonghen, Rose; Wanyama, Alli; Lamela, Eriksen, Son; Janssen
Subs: Vorm, Carter-Vickers, Davies, Dembele, Onomah, Sissoko, Winks
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