The shot-stopper was forced to pull out of the England squad during the recent international break due to a calf injury, and was subsequently a doubt for this weekend's match.
However, he has recovered in time to start in an unchanged Burnley side as they look for their first away points of the season.
Ryan Bertrand and Cedric Soares both miss out through injury, while Pierre-Emile Hojbjerg drops to the bench alongside Shane Long and Jay Rodriguez, both of whom could make their returns from injury as substitutes.
Southampton: Forster; Martina, Van Dijk, Fonte, Targett; Clasie, Romeu, Davis, Tadic; Austin, Redmond
Subs: McCarthy, Yoshida, Long, Rodriguez, Ward-Prowse, Hojbjerg, McQueens
Burnley: Heaton; Lowton, Keane, Mee, Ward; Boyd, Defour, Hendrick, Marney, Gudmundsson; Vokes
Subs: Flanagan, Kightly, O'Neill, Bamford, Robinson, Tarkowski, Arfield
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