Many pundits had predicted that Real Madrid would win the tie to reach a 13th Champions League final, but Los Blancos have it all to do at the Bernabeu following their 4-1 defeat in Germany last week.
Quite simply, Jose Mourinho's team must match the record for the biggest first-leg victory overturned in the competition's UEFA Champions League era. The last team to come back from such a deficit was Deportivo La Courna against AC Milan back in 2004.
Despite recent reports, Cristiano Ronaldo is expected to be fit to start for Madrid, who should also recall Angel di Maria. Alvaro Arbeloa will return from suspension, which may see Sergio Ramos move into a centre-back role.
Dortmund have reached the final once before back in 1997 when they defeated Juventus 3-1 to lift the trophy.
Real Madrid: DWWWLW
Possible starting lineups
Real Madrid: Lopez; Arbeloa, Ramos, Varane, Coentrao; Alonso, Khedira; Ozil, Di Maria, Ronaldo; Benzema
Dortmund: Weidenfeller; Schmelzer, Hummels, Subotic, Santana; Blaszczykowski, Bender, Gundogan; Gotze, Lewandowski, Reus
Sports Mole says: 2-1