The Premier League's bottom side couldn't end a run of six straight defeats in the league as they went down to the Saints, now under the guidance of Argentinian Mauricio Pochettino.
Read how it all unfolded in our minute-by-minute updates below.
Reading: McCarthy, Harte, Pearce, Leigertwood, McCleary, Pogrebnyak, Hunt
Saints: K Davis, Fonte, Fox, Ward-Prowse, Lallana, Guly, Puncheon
Coincidentally there is 30% off away shirts today in the club shop. So there were at least three free shirts for the ten starters...— Crystal Palace FC (@Official_CPFC) April 6, 2013