The Reds will go into the match three points clear of Jose Mourinho's side and knowing that victory would take them joint top of the table alongside Manchester City and Arsenal.
Klopp insists that his side will focus on their own game rather than worrying about United's qualities, and revealed that he is "optimistic" about picking up a positive result.
"We have a lot of things to do until the game, but we'll be ready, that's the only thing I can promise. We'll try everything, I am really looking forward to it. I am quite optimistic because we have a wonderful opportunity to play a home game under the floodlights," he told the club's official website.
"It will be a fantastic atmosphere and trying your best in a situation like this is the best thing I can imagine when I think of football. We don't think about United too much.
"We know about their strengths and where they are individually strong, experienced and all that stuff. They are a good side, but if they are not concentrating for a second, then we can use the situation. There's not a big difference between the teams. Nobody can be thinking this will be a clear result with a game decided early on."
Liverpool have lost their last four Premier League meetings with United.