The Canaries defeated the Red Devils at Carrow Road earlier in the season and are looking to do the double over Sir Alex Ferguson's men.
However, they have not won at Old Trafford since 1989 and are considered massive underdogs.
"I'd love to think we could double them and you always raise your game against Manchester United," The Mirror quotes Holt as saying.
"Nobody expects us to get anything so the pressure is off and we can just relax and play our football."
Holt has scored five goals in 23 appearances this season.