The fixture between English football's two most successful clubs is widely regarded as the biggest of the season, with Jose Mourinho's arrival at Old Trafford adding extra spice to the occasion this term.
Henderson expects the match to be an emotionally-charged affair, but talked up the importance of using that passion in the right way.
"It is the rivalry, the success both clubs have had and it's like a derby," he told LFC TV.
"The atmosphere is incredible and that transcends onto the pitch. I don't think it is one you have to get yourself pumped up for it.
"You can get pumped up for games and sometimes you can cross the line very easily in big games with the adrenaline going. You have to make sure you use that in the right way but I am sure it won't be a problem."
Liverpool have lost their last four league meetings with United.