Daley Blind and Chris Smalling are included in the defence, while Ander Herrera joins Schneiderlin in midfield, with Memphis Depay, Juan Mata and Jesse Lingard providing assistance to lone striker Anthony Martial.
Meanwhile, Shrewsbury have named an unchanged side from the one that sealed a 3-2 win over Blackpool in their League One clash on February 13.
Former United midfielder Larnell Cole returns to action after missing three games with a groin problem, but has to settle for a spot on the bench, while Jack Grimmer makes the lineup following an injury concern.
Shrewsbury Town: Leutwiler; Grandison, Whitbread, Knight-Percival; Grimmer, Whalley, Ogogo, Black, Brown; Mangan, Akpa Akpro
Subs: Halstead, Sadler, Vernon, Clark, Cole, Smith, Grandin
Manchester United: Romero; Varela, Smalling, Blind, Borthwick-Jackson; Schneiderlin, Herrera; Memphis, Mata, Lingard; Martial
Subs: Henderson, McNair, Poole, Carrick, Pereira, Riley, Keane
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