Despite signing in the summer for a fee which could reach €45m (£39.5m), Lindelof is yet to feature in the Premier League, with Mourinho instead preferring to use Eric Bailly and Phil Jones in the centre of defence.
However, with the pair suspended for the European opener with Basel, Lindelof will make his first competitive appearance for United, and Mourinho has said that he expects a strong performance from the Swedish international at Old Trafford.
The 54-year-old told reporters: "I think it is easier for him to play in the Champions League. No need to adapt, he needs a little bit of time to adapt to the Premier League."
Lindelof will partner Chris Smalling, who has also found himself left on the sidelines for the first month of the domestic campaign.