The result was only Juve's second league defeat in a year and they head into this Saturday's encounter having last faced Empoli in the 2007-08 campaign.
The visitors are favourite to snatch all three points and get themselves back on track, but Empoli could capitalise on Juve's dented spirit following their midweek loss.
Empoli boss Maurizio Sarri will host Massimiliano Allegri's side having grabbed just one victory in nine league games so far this season, which has left them 17th in the standings, just one point above the relegation zone.
Empoli had a run of draws and hadn't lost a game in five fixtures, but the team head into this weekend's match having suffered a 4-0 defeat to Cagliari and a 3-1 loss at the hands of Sassuolo on Wednesday.
Allegri is expected to be without Patrice Evra this weekend as the former Manchester United full-back is likely to be out of action for a month with a thigh injury.
Possible starting lineups
Empoli: Bassi; E Hisaj, L Tonelli, Rugani, M Rui; Zielinski, Valdifiori, Croce; M Pucciarelli, Vecino, Maccarone
Juventus: Buffon; Ogbonna, Bonucci, Chiellini, Lichtsteiner; Vidal, Marchisio, Pogba, Asamoah; Llorente, Tevez
Sports Mole says: 0-2