The hosts will enter the match rock bottom of the Premier League table - losing all four of their games this season without scoring a single goal.
Southampton, meanwhile, have collected five points from their opening four fixtures to occupy 13th position in the table.
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PALACE: Hennessey; Ward, Dann, Fosu-Mensah, Schlupp; Loftus-Cheek, McArthur, Cabaye; Puncheon, Benteke, Townsend
SAINTS: Forster; Cedric, Yoshida, Hoedt, Bertrand; Romeu, Davis, Lemina; Tadic, Long, Redmond