They are the strong favourites with the bookmakers to strengthen their grip on the summit, with the majority offering odds of 12/1 on a victory for Steve Bruce's visitors.
Manager Arsene Wenger could make changes to his starting lineup in a bid to keep his players fresh as the campaign enters the busy Christmas period.
That would potentially see Jack Wilshere drop out, with Wenger having previously admitted that he needs to carefully manage the number of games that the England international plays.
The Tigers have won just one of their six previous trips to the North Londoners.
Possible starting lineups
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Rosicky, Ramsey, Ozil, Walcott; Giroud
Hull: McGregor; Figueroa, Davies, Rosenior; Elmohamady, Meyler, Huddlestone, Livermore, Brady, Boyd; Sagbo
Sports Mole says: 2-0