Mayweather and Alvarez are both defending their respective unbeaten records, but Hatton has backed the American to be too fast for his younger opponent.
The 34-year-old told BBC Sport: "Alvarez is younger, bigger and stronger but Floyd will have the speed and movement to keep out of the way.
"He will be Floyd's toughest fight, because Floyd is getting on a bit. Having said that, he lives the life and looks after his body. He's also a master of defence so he hasn't been in too many wars, and there aren't too many miles on the clock, despite his age.
"Floyd will make Alvarez miss and any boxer will tell you that there's nothing that tires you out more than hitting fresh air continually."
The bout in Las Vegas is for the WBC and WBA light-middleweight titles.