DeRozan and Lowry scored 46 points together, 23 of them coming in the final quarter, as they helped to overturn a 14-point deficit to beat the Hawks at the Air Canada Centre.
"That is what he does. To be honest, that's Kyle," Rozan said following the victory.
"The hunger to win kicks in and when it comes down to me and him, we take onus on that and try to pull our team to victory."
The win sees the Raptors sitting in first position in the Atlantic Division, with a record of 39-30 for the season.