The Raptors defeated the Detroit Pistons 116-107 at the Palace Of Auburn Hills, as DeRozan shone with 30 points on the night.
"It definitely means a lot," DeRozan told reporters after the game. "If you really sit down and look at it, that's big, to be tied with the franchise record and have a chance to break it.
"We've come a long way. A lot of people wouldn't have counted us to be in the position we're in now. It's definitely a credit to our hard work, both the players and the coaching staff."
The franchise record currently stands at 47 wins in a regular season, with Toronto needing one win from their final games to set a new tally.