Aaron Rodgers, Calvin Johnson and Ryan Clady will all miss the Pro Bowl due to injuries.
Three more changes have been announced to this year's Pro Bowl roster.
Green Bay Packers quarterback Aaron Rodgers has said that he will not be able to take part in the annual all-star game, citing numerous injuries to his ankle, calf and knee.
His place has been taken by Eli Manning of the New York Giants.
Andrew Whitworth from the Cincinnati Bengals takes the place of Denver Broncos left tackle Ryan Clady.
Detroit Lions wide receiver Calvin Johnson also drops out, with Vincent Jackson of the Tampa Bay Buccaneers stepping in.
Drew Brees, Chad Greenway and Jermaine Gresham had already been added to the original list of names following injuries late in the season.
The Pro Bowl features the best players from the NFL's two conferences going head to head the week before the Super Bowl.
Brees added to Pro Bowl roster >