Sanchez threw an interception that was returned for a touchdown, reigniting concerns over his form after a poor season last year.
Ryan made no effort to defend the under-fire quarterback, saying that he should have thrown the ball away rather than trying to find teammate Tommy Bohanon.
"I said, 'Oh, shoot'. I said something with an S," Ryan told reporters. "He clearly made a mistake on the interception. It was a huge error. You've got to get rid of that ball."
Sanchez also admitted his mistake, acknowledging that he should have thrown the ball out of play.
"If it's a dead play, it's a dead play. Just let it go and dirt it," he said.
Sanchez is currently under pressure from rookie Geno Smith for the starting quarterback jersey ahead of the new season.