In the latest in a long line of meetings between the two future Hall of Famers, Manning came out on top, throwing for 400 yards and two touchdowns to guide the Broncos to their first Super Bowl since 1998.
It was the latest fine performance in a record-breaking season for Manning, and Brady was quick to pay tribute to the veteran after the match.
"I have a lot of respect for him. Certainly, he's a great player and he played great today," Brady told The AP.
The Broncos will face the Seattle Seahawks in the Super Bowl on February 2.