The Colts produced a good all-round display of both offense and defense as they staked their claim for a successful stretch run in the remaining weeks ahead.
"We're not exhaling. The division is not sewn up," said Pagano after the game.
"I'm really proud of the defense playing the way they did. They were asked time and time and time again to go out there and make stops. The turnovers were huge."
The result leaves the Colts in first position in the AFC Southern Division, with a record of 8-4.