Pagano further stressed the importance of defending their star asset and reassured Irsay that his message was being drilled into his side during training.
"That's every week, you know. That's [emphasized in] all of our offices and every office up and down the hallway," Pagano told reporters.
"We all know that as long as No. 12 [Luck] is upright and on his feet, we've got a much better chance of winning with him."
The Colts will look to continue their winning start to the new season when they take on the Miami Dolphins on Sunday.