The veteran signal-caller is currently on 506 career touchdown passes, just two behind Brett Favre's NFL record of 508.
"I think we've concentrated on important things; we've had two good wins coming off a bye week," Manning said, ESPN reports.
"That's what I've concentrated on, kind of doing whatever it takes to win. I don't feel like it's been a distraction."
Tight end Jacob Tamme echoed Manning's thoughts by insisting that the focus for the team is on defeating the 49ers, who are 4-2 so far this season.