Pickett quickly took the ascendancy against the bigger Jabouin, landing shots to the body to test the Canadian's durability.
The East London native followed that up with a spinning kick attempt, which was stuffed by Jabouin.
A tentative fight took a dramatic twist after three minutes of the first round when Pickett landed a huge right uppercut to floor his opponent.
'One Punch' Pickett followed up with a flurry of hits to force Leon Roberts to end the contest.
A huge win for Pickett improves his record to 22-6 and puts him in contention for a shot at UFC bantamweight champion Dominick Cruz.