In total, manager Mick McCarthy has made ten changes to the side that drew with Tottenham Hotspur in the Premier League on Saturday, with Christophe Berra the only player who keeps his place.
Dorus de Vries is chosen ahead of Wayne Hennessey in goal, while Kevin Doyle has been partnered with Sylvain Ebanks-Blake up front.
Meanwhile, there is no Marlon King or Nikola Zigic in Chris Hughton's starting lineup.
Adam Rooney and Jean Beausejour have been selected in attack, with Nathan Redmond retaining his place in midfield.
Wolves: De Vries; Doherty, Berra, Stearman, Elokobi; Hammill, Milijas, Jonsson, Hunt; Ebanks-Blake, Doyle
Subs: Hennessey, Henry, Fletcher, Ward, Keogh, Guedioura, Forde
Birmingham: Doyle; Spector, Caldwell, Davies, Murphy; Redmond, Gomis, Mutch, Elliott; Beausejour, Rooney
Subs: Butland, Valles, Fahey, Gnahore, Burke, King, Zigic