Troy Deeney pulled a goal back for the Hornets during the closing stages, but it was too little too late as Stoke held on for the win.
Read below to see how the action unfolded at Vicarage Road.
Hello, and welcome to Sports Mole's live coverage of the Premier League match between Watford and Stoke City.
With only seven minutes to go until kickoff, let's get straight to the teams!
WATFORD XI: Gomes; Nyom, Britos, Cathcart, Ake; Behrami, Suarez, Capoue; Jurado, Deeney; Ighalo
WATFORD SUBSTITUTES: Pantilimon, Prodl, Watson, Abdi, Anya, Guedioura, Amrabat
STOKE CITY XI: Butland; Bardsley, Cameron, Wollscheid, Muniesa; Whelan, Imbula; Walters, Afellay, Arnautovic; Joselu
STOKE CITY SUBSTITUTES: Haugaard, Ireland, Adam, Diouf, Teixeira, Crouch, Krkic
Odion Ighalo was a doubt for Watford, but the club's top goalscorer starts. However, Quique Sanchez Flores has made three alterations, with Miguel Britos, Mario Suarez and Jose Jurado all taking their place in the starting lineup.
As for Stoke, Mark Hughes has made four changes, with Phil Bardsley, Marc Muniesa, Jon Walters and Joselu all coming into the side.
Stoke get us underway at Vicarage Road!
Good start from Watford, who almost create an opportunity through Ighalo but the Hornets player cannot find strike partner Deeney with his pass.
Stoke are having a lot of the ball but Watford are defending in numbers. You wouldn't expect too many goals between these two sides and although it is early days, it doesn't look like the kind of the game that will produce many this afternoon.
It's Watford who create the first chance of the game through Ighalo, but despite Ighalo getting the better of Wollscheid, he cannot beat Butland, who gets down low to prevent the ball from finding the bottom corner.
A few Stoke crosses have gone astray during the opening stages and it is no different when Walters gets into some space on the flank. He tried to roll a low pass across the penalty area but is was easily defended by the Hornets.
Stoke are the underdogs in this game but a draw wouldn't really suit them. They are safe from relegation so they have little reason not to go for maximum points at places like Watford. They are probing away on either side of the pitch, but as of yet, nothing has tested Gomes.
GOAL! Watford 0-1 Stoke City (Walters)
It must have been my words of encouragement! Stoke take the lead at Vicarage Road through Walters, who converts at the back post after being found by Bardsley. A driving run from Imbula started the move.
It's all Stoke now and Arnautovic has an opportunity to double the lead after beating the Watford offside trap. However, he doesn't connect cleanly with his shot and it goes wide of the target.
Watford need to try to regain a foothold in this match. They started well but since the quarter-hour mark, Stoke have taken over. It's a little too soon for the Hornets to be distracted by the FA Cup semi-finals.
CHANCE! After a couple of free kicks come to nothing, Watford make more of a corner but Deeney's header is off target. They've been a bit better over the last few minutes but Stoke look comfortable.
Watford are slowly starting to build a head of steam but they cannot force Butland into any kind of significant save. Stoke have been struggling for defenders of late, but even without Shawcross, they look a tough unit today.
Stoke have the ball in the net when Arnautovic converts a Bardsley cross but the assistant raises his flag for offside. It's a very tight call, but the correct one.
UPDATE! Elsewhere in the Premier League, West Ham are leading at Chelsea and Leicester are ahead at Crystal Palace. So far, it's a day for the visitors.
BOOKING! The first caution of the afternoon goes to Capoue, who is booked for a foul on Imbula.
CHANCE! That was an opportunity for Watford. A delicate flick from Ighalo finds Jurado, but after moving into a shooting position, he sends the ball high into the stands. He should have done better.
HALF TIME: Watford 0-1 Stoke City
The half-time whistle goes at Vicarage Road and a close-range finish from Walters is the difference between the two sides. There haven't been that many opportunities but Stoke won't care - they are 45 minutes away from an important three points.
We are back underway at Vicarage Road. What have the Hornets got to offer in this second half?
Ighalo is presented with a half-chance in the opening seconds but his speculative effort was off target. Still, it gives Watford the platform to get onto the front foot. They did to shake things up in the Stoke defence.
GOAL! Watford 0-2 Stoke City (Joselu)
Watford started the second half the stronger of the two, but it's Stoke who go 2-0 ahead! A long ball is hooked into the path of Joselu by Walters, and Joselu produce a bit of brilliance to loft the ball over Gomes. That's the Spaniard's fourth goal of the Premier League campaign.
SUBSTITUTIONS! Flores has acted - he had no other choice. Amrabat and Guedioura have been introduced in place of Jurado and Behrami.
Stoke are all over Watford now and after Arnautovic retrieves possession for the Potters, Afellay is given an opportunity to shoot but Gomes makes the save by tipping the ball wide for a corner.
The intensity of the game has dropped a touch now. Have Watford got the desire to get back into this game? You have to say that Stoke have been very impressive.
As it stands, Stoke are moving two places up to seventh. It would leave just a point behind Manchester United, but the Old Trafford outfit have two games in hand.
The introduction of Amrabat and Guedioura has livened things up for Watford but still, they cannot muster up a clear opportunity. I suspect Mark Hughes will freshen things up himself soon in order to see out this match.
SHOT! Amrabat gets a shot on target, but rather than shouts of encouragement, it brings sarcastic cheers from the home support. They appear less than impressed with their team's attacking performance this afternoon.
SUBSTITUTION! Flores makes his final alteration, throwing on Ikechi Anya for Nathan Ake. You feel it might be too little too late.
A clearance from Butland is expertly controlled by Walters but after he works the ball to Arnautovic, the Serbian can't connect properly and Gomes is able to claim.
SHOT! The game is opening up slightly, which will suit Watford, but they cannot capitalise as Suarez blazes a shot high over the crossbar after being set up by Amrabat.
Butland advances out of his goal and it gives Deeney the chance to try to lob the England international, but his effort is lacking in power and flight. Not long to go now. Stoke look like seeing this out with minimal fuss.
GOAL! Watford 1-2 Stoke City (Deeney)
Watford are back in it! Anya has been lively since coming on and he works his way into a position to cross for Deeney, who gets ahead of the Stoke defence to head the ball home. Game on!
The home side are throwing men forward now. This seemed so unlikely a few minutes ago!
There will be four minutes of added-on time.
More Watford pressure. This would be an undeserved point if they were to grab an equaliser...
FULL TIME: Watford 1-2 Stoke City
The full-time whistle goes at Vicarage Road and Stoke have held on to earn a 2-1 win. It got nervy at the end but the Potters were full value for the three points.
That will be all from Sports Mole for this match. Thanks for joining us this afternoon and we hope that you can stick around for all of the reaction that is coming your way. Goodbye for now.