Heckingbottom is not expected to make too many changes to the starting lineup that beat Brighton & Hove Albion last weekend, but Chelsea loanee Ethan Ampadu could be one player who is recalled to the side at the expense of Jayden Bogle.
John Fleck, Oliver Norwood and Ben Osborn are likely to form a partnership in central midfield while Rhian Brewster, who is yet to score for the Blades, could keep his place up front alongside David McGoldrick.
McGoldrick found the net for the seventh time this season against the Seagulls last weekend, which means he has now scored 39% of Sheffield United's Premier League goals this campaign, the highest ratio in the division.
Sheffield United possible starting XI: Ramsdale; Ampadu, Egan, Bryan; Baldock, Fleck, Norwood, Osborn, Stevens; McGoldrick, Brewster
Watch the Sports Mole Football Shorts prediction for this game below: