Kane had been out of action for over a month with an ankle injury and made a brief appearance from the substitutes bench in last week's 4-0 win over Watford.
For Bournemouth, they make one change from the side that was beaten 3-1 by Chelsea last weekend, with Junior Stanislas making his first appearance since a 2-0 defeat to Crystal Palace in late January.
Tottenham Hotspur: Lloris, Walker, Alderweireld, Vertonghen, Davies, Dier, Dembele, Son, Eriksen, Dele, Kane
Subs: Lopez, Trippier, Wimmer, Wanyama, Onomah, Sissoko, Janssen
Bournemouth: Boruc, Smith, Francis, S Cook, Daniels, Stanislas, Arter, Wilshere, Pugh, King, Afobe
Subs: Allsop, Mings, Cargill, L Cook, Fraser, Gradel, Mousset
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