Spurs will enter the match off the back of an impressive 5-2 victory over Southampton in the Premier League on Sunday afternoon and have now won their last two games in all competitions.
Jose Mourinho will be determined to bring a trophy to the Tottenham Hotspur Stadium this season, but an incredibly crowded fixture list means that wholesale changes are expected to occur for this game.
Here, Sports Mole looks at how Tottenham could line up against Orient.
Tottenham will be without the services of Japhet Tanganga due to a thigh problem, while new signing Gareth Bale is out until October with a knee injury and will therefore not be involved in any capacity.
Mourinho is expected to make wholesale changes from the side that faced Southampton, and there could be a debut for former England number one Joe Hart between the sticks, while Dele Alli could come into the side despite the recent speculation surrounding his future.
There are also likely to be a number of youngsters in the squad, and there could be a starting role for 18-year-old defender Dennis Cirkin on the left side of the back four.
Tanguy Ndombele was substituted at the interval of the clash with Southampton, but Mourinho insisted after the match that the Frenchman was not injured, and he could be involved in this game.