The Manchester United goalkeeper is suffering from stomach issues and does not feature, with former Liverpool stopper Reina lining up in between the sticks.
For Colombia, Real Madrid attacker James Rodriguez - whose future at the Bernabeu is unclear - is picked from the off, alongside Juventus winger Juan Cuadrado, whose brief cameo in the Champions League final saw him dismissed.
Spain: Reina, Azpilicueta, Pique, Nacho, Alba, Illarramendi, Koke, Iniesta, Pedro, Silva, Aspas
Colombia: Ospina, Arias, Zapata, D. Sanchez, Armero, Aguilar, C. Sanchez, Garcia, James, Cuadrado, Cardona
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