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This will be a huge test for Ryan Giggs's side tonight as they take on a Spain team eager to bury their woeful World Cup memories, and it will be interesting to see if they can put up much of a fight without Gareth Bale here.
Let's start with a look at who will be replacing Bale in the team...
Spain were hit by a few notable retirements in the wake of their World Cup disappointment - namely Iniesta, Pique and David Silva - but there are still plenty of recognisable names in the squad for this evening's trip to Cardiff.
Indeed, despite most of the names being familiar in that team, there are a few other players who are still inexperienced at this level, with Jose Gaya, Dani Ceballos and Suso all making just their second appearances for Spain.
Morata is joined in the front three by Paco Alcacer - who has six goals in 13 international appearances - and former Liverpool forward Suso.
Centre-back partner Raul Albiol is the only only player in the team who has won more than 50 caps for Spain, although there is still plenty of top-level experience in the shape of David de Gea, Cesar Azpilicueta and Saul Niguez.
Well, the headline news around Wales will almost always be about Gareth Bale, and as manager Ryan Giggs confirmed before the game, the Real Madrid man does not feature tonight due to ongoing concerns over a groin injury.
Giggs is, however, hopeful that the Wales talisman will be fit for the match against Ireland on Tuesday.
Vokes has been in decent form for Burnley so far this season and will be a handful for any defence - if only due to his physicality - but he will be the first to admit that he doesn't offer the same level of threat as Bale.
The most experienced, meanwhile, is Chris Gunter, who will be winning his 90th Wales cap this evening. He takes his role in what could be a five-man defence for Wales, with Giggs naming two recognised left-backs and right-backs to help protect down the flanks.
Williams himself has acknowledged that he needs to be be playing well for club side Stoke if he wants to be selected for his country, but tonight will be a chance for him to silence his doubters against some of the very best in the world.
It is certainly the toughest test of his fledgling managerial career so far, and Welsh fans would be forgiven for fearing the worst after seeing the World Cup runners-up put the the sword by tonight's opponents last time out.
Those two defeats both came against opposition Wales may have been expected to lose to - Uruguay and Denmark - but Giggs will no doubt be looking to focus on the positive and his side's wins certainly contain plenty of those.
That victory over Ireland not only saw them exact some revenge for defeat in a crucial World Cup qualifier one year ago, but it also showcased an exciting and attacking young team which is being moulded by Giggs.
However, he has also lost two of his first five games at the helm, which is as many games as they had lost in the previous 12 outings before his appointment.
That defeat brought Wales back down to earth just three days after their 4-1 triumph over Ireland, and now they risk losing two games on the bounce for only the second time in more than two years - and the first time under Giggs.
Their record in friendly matches is also poor, failing to win any of their last eight non-competitive outings stretching all the way back to March 2014 = losing five in that time. What's more, they have failed to even score in five of those eight matches.
Another victory for Wales tonight - unlikely as it might seem right now - would hand Wales back-to-back home wins for the first time since June 2015, although they have not played at this stadium since losing to England here in 2011.
Of course, more time is needed to determine whether they will be able to return to their former glories any time soon, but new boss Luis Enrique certainly seems to have them moving back in the right direction.
As ever, La Roja were regarded as one of the favourites to lift the trophy, but some shaky form during the buildup preceded one of the most remarkable twists in World Cup history when Spain sensationally sacked unbeaten boss Julen Lopetegui on the eve of the tournament.
Lopegetui's departure surely had a fairly substantial impact on Spain's World Cup, despite Fernando Hierro's best efforts, and Spain eventually crashed out in the last 16 following a penalty shootout defeat to host nation Russia.
Since then, though, things have begun to look a lot brighter again for Spain, with Luis Enrique now fully rested following a sabbatical from the game and eager to make a quick impact while in charge of the national team.
I have mentioned that result a few times already tonight, and Spain certainly won't want to forget dishing out Croatia's heaviest ever competition defeat, but the other victory was also impressive in their own right as they came from behind to beat England at Wembley.
Indeed, you have to go back to the last 16 at Euro 2016 for their last defeat inside normal time - a run of 26 matches across all competitions which includes 17 victories.
La Roja's record in friendlies is also ominous for Wales, with no defeats in their last 10 and only one loss from their last 17.
It is hard to see Wales winning this one without being able to call upon Bale, even with the home crowd behind them. Spain simply have the superior quality and if they can put Croatia to the sword, then they can do the same against Wales tonight.
SPORTS MOLE SAYS: Wales 0-3 Spain
However, Spain have only won two of those previous five matches, with two of those games ending all squad and Wales winning the other.
Wales boasted some brilliant players in that era - as demonstrated by the goals coming from Ian Rush (2) and Mark Hughes, although Spain did win the reverse fixture in World Cup qualifying by the same margin.
That occasion ended in a 1-1 draw in 1982, with Robbie James scoring for Wales to cancel out Satrustegui's opener for the hosts.
WALES: Hennessey; Gunter, Williams, Davies; Roberts, Allen, Ampadu, John; Wilson, Vokes, Ramsey
SPAIN: De Gea; Azpilicueta, Ramos, Albiol, Gaya; Saul, Rodri, Ceballos; Suso, Morata, Alcacer
Hennessey comes out to punch a cross from the right flank and does so bravely, but it only goes as far as Gaya. His shot is dragged and eventually falls into the path of Alcacer, who fires his finish into the roof of the net.
It is truly dreadful defending from the home side as Ceballos floats a cross into the box and a few Spain players are queuing up completely unmarked in the middle. It is Ramos of all people to gets his head to it, nodding it back across goal and into the far corner.
The ball bounces about inside the box and Allen and Wilson get in each other's way when trying to clear it, with the latter sending it looping into an even more dangerous position. Alcacer reads it, and volleys his finish past Hennessey from close range.
3 - Wales have conceded three goals in the first-half of a home match for the first time since facing Slovakia in October 2006, in a match they eventually lost 1-5. Outclassed. #WALESP— OptaJoe (@OptaJoe) October 11, 2018
The visitors lead by three goals against Wales and I can only see them increasing that advantage in the second half. Wales have simply been outclassed in this match so far.
Hennessey had come out to punch a cross from the right, but his clearance only made it as far as Gaya. Gaya's shot was scuffed, but eventually fell at the feet of Alcacer, who fired it past the Wales keeper.
Ceballos's delivery could have found as many as three Spanish players completely unmarked, and it should not have come as a surprise that Ramos was one of them - nor that he nodded his effort past Hennessey.
This time it was Wilson and Allen who got in each other's way, with Wilson only diverting the ball into the path of Alcacer, who lashed his finish past Hennessey.
It is a special moment for Bartra as he scores his first international goal, and it is a really good header too as he rises highest to meet a corner and flicks his effort into the far corner. Nothing Hennessey could do there.
Once again Brooks is involved, delivering a beauty of a cross with the outside of his left foot which Vokes meets to steer a header into the bottom corner past Kepa.
There is no doubt that Spain are deserved winners tonight, though, having outclassed Wales from the very first whistle. Goals from Paco Alcacer either side of a Ramos header put the result beyond doubt before the half-hour mark, and a fourth from Marc Bartra was no more than they deserved.
Thank you very much for joining Sports Mole for tonight's match as Spain outclass Wales in Cardiff to make it three wins from three under Luis Enrique. I will leave you with our match report, and be sure to check back in for plenty more live international football over the coming days.
From me, though, it is goodbye for now!