Artur Boruc and Gaston Ramirez face late fitness tests for the home side, while Jay Rodriguez is out for a long time after his bad knee injury last week.
Cardiff have injury problems of their own with Craig Noone, Kenwyne Jones and Ben Turner all expected to miss out.
Follow all the action with Sports Mole's live coverage below. Please note that the match kicks off at 3.07pm.
Southampton: Cropper, Clyne, Wanyama, Ward-Prowse, Guly, Hooiveld, Gallagher
Cardiff: Lewis, Turner, Eikrem, Gunnarsson, McNaughton, Zaha, Bellamy