After overcoming Celtic in the final qualifying round, Maribor started the group stages with a last-gasp draw at home to Sporting Lisbon to get their campaign off to a positive start.
The Slovenian champions haven't been at their best in domestic action, but they are unbeaten in their last five games in all competitions and won't fear their trip to Gelsenkirchen.
Striker Welle N'Diaye is a fitness doubt after being withdrawn late on in the draw with NK Radomlje.
Schalke 04: LDDWW
Possible starting lineups
Schalke 04: Fahrmann, Uchida, Matip, Boateng, Aogo, Draxler, Neustadter, Hoger, Meyer, Huntelaar, Choupo-Moting
Maribor: Handanovic, Suler, Rajcevic, Mejac, Trajkovski, Vrsic, Filipovic, Mendy, Biton , Bohar, N'Diaye
Sports Mole says: 3-1