Struggling Novara started the brighter of the two sides and went on to break the deadlock in the 17th minute. Giuseppe Gemiti sent over a cross to Andrea Caracciolo and the former Sampdoria striker headed into the corner of the net.
Osvaldo went on to find the net in the 34th minute to give his side the lead at the break by heading in a lofted pass from captain Francesco Totti.
Fabio Simplicio extended Roma's lead after the restart when he curled an effort in to the top right-hand corner of the net with 53 minutes played.
Visiting Novara managed to add their second of the game in the 77th minute when Takayuki Morimoto struck from close range.
There was still time for Roma to find their fifth of the afternoon courtesy of Argentine Erik Lamela in stoppage time.
Despite the victory, Roma remain sixth in the Serie A table.